HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-butanal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-(4,4-Diethoxybutyl)isoindoline-1,3-dione | HCID 12805186 | — |
| Solvent | 4,4-Diethoxybutylamine | HCID 80672 | — |
| Product | 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-butanal | HCID 77150 | — |
Reaction Steps
Protect the amino function in 4,4-diethoxybutylamine by conversion thereof to a phthalimido function. Hydrolyze the resultant 1-phthalimido-4,4-diethoxybutane with 1N aqueous sulfuric acid at 25° C to obtain 4-phthalimidobutanal. Subject the compound to reductive amination using ammonium chloride and sodium cyanoborohydride in aqueous methanol at 25° C to obtain 4-phthalimidobutylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04009328 |
| Source dataset | uspto-grants-1977_02 |
| ORD ID | ord-3a306dee696a447e8932b041cbcf69d2 |
| Source note | uspto-grants-1977_02 |