5-Methylthio-1,3,4-thiadiazol-2-yl isocyanate → HCID 54373746, compound
Reaction equation
[CH3:1][S:2][C:3]1[S:7][C:6]([N:8]=[C:9]=[O:10])=[N:5][N:4]=1.[CH2:11]([NH:17][CH2:18][CH:19]=[O:20])[CH2:12][CH2:13][CH:14]=[CH:15][CH3:16]>C1C=CC=CC=1>[CH2:11]([N:17]([CH2:18][CH:19]=[O:20])[C:9]([NH:8][C:6]1[S:7][C:3]([S:2][CH3:1])=[N:4][N:5]=1)=[O:10])[CH2:12][CH2:13][CH:14]=[CH:15][CH3:16]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 5-methylthio-1,3,4-thiadiazol-2-yl isocyanate dimer (0.05 mole), the diethyl acetal of 2-hex-4-enylaminoacetaldehyde (0.1 mole) and benzene (60 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and reflux condenser. The reaction mixture is heated at reflux for a period of about 15 minutes. After this time the mixture is stripped of benzene under reduced pressure to yield a solid product as the residue. The residue is then recrystallized to yield the desired product the diethyl acetal of 2-[1-hex-4-enyl-3-(5-methylthio-1,3,4-thiadiazol-2-yl)ureido]acetaldehyde.