2-Acetoxy-3-dimethylamino-1,1-diphenyl-propane → 3-Dimethylamino-1,1-diphenyl-propan-2-ol
Reaction equation
C([O:4][CH:5]([CH2:19][N:20]([CH3:22])[CH3:21])[CH:6]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=O)C>[OH-].[K+]>[CH3:22][N:20]([CH3:21])[CH2:19][CH:5]([OH:4])[CH:6]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Acetoxy-3-dimethylamino-1,1-diphenyl-propane (200 mg) was dissolved in methanolic potassium hydroxide (5% 10 ml.) and the solution allowed to stand overnight. Solvent was evaporated and the residue dissolved in ether and water. The ether extract was dried and evaporated to give 3-dimethylamino-1,1-diphenyl-propan-2-ol (170 mg., 97%), m.p. 72° - 73°.
Workup
- customSolvent was evaporated