Potassium Hydroxide → HCID 21429937, compound
Reaction equation
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[N:10]=[C:9]([Cl:11])[C:8]([Cl:12])=[N:7][C:6]=1Cl.[OH-].[K+]>C1C=CC=CC=1>[Cl:11][C:9]1[C:8]([Cl:12])=[N:7][C:6]2[O:1][CH2:2][CH2:3][NH:4][C:5]=2[N:10]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
(2-Hydroxyethylamino)-trichloropyrazine (12.1 g, 0.05 mol) and crushed KOH (5 g, 85% assay, 0.075 mol) were contacted in refluxing benzene overnight. The solid phase was filtered out and stirred in water, CH2Cl2, and IPA and refiltered after each wash to give 3 g (30% yield) of an off-white solid.
Workup
- filtrationThe solid phase was filtered out and
- washeach wash
Sources & evidence
- ORD record
- ord-9d964a81c97a4ef0b7e2b401b0ec3a93
- Source dataset
- uspto-grants-1977_06
- Patent number
- US04029657
Reaction notes
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