2-(Aminomethyl)-4-tert-butyl-6-iodophenol--hydrogen chloride (1/1) → 2-Aminomethyl-4-t-butyl-6-iodophenol

HRID 437210

Reaction equation

HRID 437210 reaction equation
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[C:6]([I:14])[C:5]=1[OH:15]>O>[NH2:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]([CH3:11])([CH3:13])[CH3:12])[CH:7]=[C:6]([I:14])[C:5]=1[OH:15]

Participants

3

Reactant 1

HCID 126342632-(Aminomethyl)-4-tert-butyl-6-iodophenol--hydrogen chloride (1/1)

Product 1

HCID 1192862-Aminomethyl-4-t-butyl-6-iodophenol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A freshly-prepared solution of 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol hydrochloride (5 g., 15 millimole) in water (100 ml.) is stirred at room temperature and basicified to pH ca.8 by addition of 15N ammonium hydroxide (excess) providing a fine slurry which is stirred at room temperature for 10 minutes and filtered. The collected solid is washed with water and dried in vacuo at 80° C. over phosphorous pentoxide for 2 hours to provide 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol as a colorless solid (4.2 g.), m.p. 146°-146.5° C. (dec.).

Workup

  1. customproviding a fine slurry which
  2. filtrationfiltered
  3. washThe collected solid is washed with water
  4. dry with materialdried in vacuo at 80° C. over phosphorous pentoxide for 2 hours

Sources & evidence

ORD record
ord-dfc3f9ae436245ae879c9dae21e62968
Source dataset
uspto-grants-1977_06
Patent number
US04029816

Linked notes

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