HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Thiazolecarboxylic acid → HCID 86648680, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Thiazolecarboxylic acid | HCID 304271 | — |
| Reactant | cis(+/-)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride | HCID 86648665 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86648680 | HCID 86648680 | 42.2% |
Reaction Steps
cis(±)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride obtained in Example (131a) (100 mg, 0.297 mmol) and 4-thiazolecarboxylic acid (39 mg, 0.30 mmol) were suspended in DMF (3 mL). The suspension was subjected to the same operation as in Example (138a) to obtain 51.6 mg of the title compound as a colorless solid (42%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536197B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-06d8a7175859426fac1988f1cf2a7ff1 |
| Source note | uspto-grants-2013_09 |