HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pinacolone → Methyl pivaloylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pinacolone | HCID 6416 | — |
| Reactant | Dimethyl Carbonate | HCID 12021 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Solvent | Hexamethylphosphoramide | HCID 12679 | — |
| Product | Methyl pivaloylacetate | HCID 99597 | 83.5% |
Reaction Steps
60 g of sodium hydride were suspended in 450 cc of dimethyl carbonate and 100 cc of hexamethyl phosphoric acid triamide. 100 g of pinacolone (92%) were added slowly at 45° C and on completion of the addition, the reaction mixture was processed as described in 3 above. The yield was 83.5% of pivaloyl acetic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04031130 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-0fb85a1d813f4f5ea5765711fed7dda6 |
| Source note | uspto-grants-1977_06 |