Butyl Isothiocyanate → HCID 21427814, compound

HRID 437508

Reaction equation

HRID 437508 reaction equation
[CH:1]([NH:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)=[O:2].[CH2:12]([N:16]=[C:17]=[S:18])[CH2:13][CH2:14][CH3:15]>C(O)C>[CH2:12]([NH:16][C:17](=[S:18])[NH:11][C:8]1[CH:9]=[CH:10][C:5]([NH:4][NH:3][CH:1]=[O:2])=[CH:6][CH:7]=1)[CH2:13][CH2:14][CH3:15]

Participants

4

Reactant 2

HCID 11613Butyl IsothiocyanateHCID 113189Hydrazinecarboxaldehyde, 2-(4-aminophenyl)-

Product 1

HCID 21427814HCID 21427814, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Formyl-2-(4-aminophenyl)hydrazine (7.5 g, 0.05 mole) and butyl isothiocyanate (5.7 g, 0.05 mole) were mixed in ethanol (120 ml) and the mixture was refluxed for 30 minutes. The resulting solution was chilled in ice and upon scratching the product crystallized out as a white solid. The mixture was filtered and the solid was washed with ether. The product was dried to give a pale tan crystalline powder. Yield 9.8 g (74%), m.p. 129°-131° C.

Workup

  1. temperaturethe mixture was refluxed for 30 minutes
  2. temperatureThe resulting solution was chilled in ice
  3. customcrystallized out as a white solid
  4. filtrationThe mixture was filtered
  5. washthe solid was washed with ether
  6. customThe product was dried
  7. customto give a pale tan crystalline powder

Sources & evidence

ORD record
ord-634785fa5bdd4c95b79e83f97e19bd12
Source dataset
uspto-grants-1977_06
Patent number
US04031127

Linked notes

Loading…