p-Fluorotoluene → 4-(4-Methylphenoxy)piperidine

HRID 437559

Reaction equation

HRID 437559 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.F[C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=1>>[C:19]1([CH3:22])[CH:20]=[CH:21][C:16]([O:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 9603p-FluorotolueneHCID 784611-Benzylpiperidin-4-ol

Product 1

HCID 38374974-(4-Methylphenoxy)piperidine

Procedure

By following the manipulative procedures described in Example 1(a) and (b), 24.0 g of 1-benzyl-4-piperidinol and 24.0 g of p-fluorotoluene produces an oil of 4-(p-tolyloxy)piperidine.

Sources & evidence

ORD record
ord-0708f67d88fd4701b56d46fb21ba0da6
Source dataset
uspto-grants-1977_06
Patent number
US04031221

Linked notes

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