HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Indoleglyoxylyl chloride → 1-(Indol-3-ylglyoxyloyl)-4-(p-fluorophenoxy)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Indoleglyoxylyl chloride | HCID 89952 | — |
| Reactant | 4-(4-Fluorophenoxy)piperidine | HCID 3734896 | — |
| Product | 1-(Indol-3-ylglyoxyloyl)-4-(p-fluorophenoxy)piperidine | HCID 21428700 | — |
Reaction Steps
By following the manipulative procedure described in Example 4(b), 4-(p-fluorophenoxy)piperidine is reacted with indole-3-glyoxyloyl chloride to give 1-(indol-3-ylglyoxyloyl)-4-(p-fluorophenoxy)piperidine as an off-white solid. The solid is recrystallized twice from a methanol and water mixture to give white needles of the glyoxamide, m.p. 205°-207° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04031221 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-6a6ad0c756cf4b878f2a1ef7fb2e16d2 |
| Source note | uspto-grants-1977_06 |