p-Fluoronitrobenzene → 1-Methyl-2-(4-nitrophenoxymethyl)-5-nitro-imidazole

HRID 437584

Reaction equation

[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[CH2:10][OH:11].[N+:12]([C:15]1[CH:20]=[CH:19][C:18](F)=[CH:17][CH:16]=1)([O-:14])=[O:13]>>[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[CH2:10][O:11][C:18]1[CH:19]=[CH:20][C:15]([N+:12]([O-:14])=[O:13])=[CH:16][CH:17]=1

Participants

Reactant 2

HCID 9590p-Fluoronitrobenzene

HCID 5573562-Hydroxymethyl-1-methyl-5-nitroimidazole

Product 1

HCID 214290951-Methyl-2-(4-nitrophenoxymethyl)-5-nitro-imidazole

Procedure

m.p. 150° C, from 15.7 g (0.1 mole) of 1-methyl-2-hydroxymethyl-5-nitro-imidazole (MHNI) and 14.1 g (0.1 mole) of 4-nitrofluorobenzene.

Sources & evidence

ORD record: ord-9d0911b08f1a4952b06901010d3013e0
Source dataset: uspto-grants-1977_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04031232

Linked notes

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