Ammonia → n-Propyl 3-iminobutyrate
Reaction equation
[NH3:1].[C:2]([O:8][CH2:9][CH2:10][CH3:11])(=[O:7])[CH2:3][C:4]([CH3:6])=O>C(OCC)C>[NH:1]=[C:4]([CH3:6])[CH2:3][C:2]([O:8][CH2:9][CH2:10][CH3:11])=[O:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Ammonia gas was passed into a stirred solution of n-propyl acetoacetate (prepared by the method of Fisher, J.A.C.S., 1934, 56, 1766; 72 g.) in diethyl ether (100 ml.) at ambient temperature for 20 hours. The solution was then dried over sodium sulphate, filtered and distilled under reduced pressure to give n-propyl 3-iminobutyrate (18.2 g.), b.p. 114°-118° C./20 mm Hg.
Workup
- customprepared by the method of Fisher, J.A.C.S
- dry with materialThe solution was then dried over sodium sulphate
- filtrationfiltered
- distillationdistilled under reduced pressure
Sources & evidence
- ORD record
- ord-b608b651696b4c5ab8accea8bcea36c1
- Source dataset
- uspto-grants-1977_06
- Patent number
- US04032323
Reaction notes
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