HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → Benzyl cis(+/-)-[3-methoxy-1-(6-methylpyrimidin-4-yl)piperidin-4-yl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Chloro-6-methylpyrimidine | HCID 581796 | — |
| Reactant | Benzyl cis(+/-)-[3-methoxypiperidin-4-yl]carbamate hydrochloride | HCID 86648698 | — |
| Product | Benzyl cis(+/-)-[3-methoxy-1-(6-methylpyrimidin-4-yl)piperidin-4-yl]carbamate | HCID 86648724 | — |
Reaction Steps
The same operation as in Example (158a) was performed using benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride obtained in Example (160a) (549 mg, 1.83 mmol), 4-chloro-6-methylpyrimidine (235 mg, 1.83 mmol) and diisopropylethylamine (709 mg, 5.48 mmol), to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536197B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-2b22532a8c924b11bd7247ef9245e68d |
| Source note | uspto-grants-2013_09 |