Methyl cis(+/-)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-fluorobenzoate → Methyl cis(+/-)-3-(4-amino-3-methoxypiperidin-1-yl)-5-fluorobenzoate
Reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:25]=[C:26]([F:28])[CH:27]=2)[C:21]([O:23][CH3:24])=[O:22])[CH2:14][C@H:13]1[O:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:25]=[C:26]([F:28])[CH:27]=2)[C:21]([O:23][CH3:24])=[O:22])[CH2:14][C@H:13]1[O:29][CH3:30]Participants
3
Procedure
The same operation as in Example (160c) was performed using methyl cis(±)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-fluorobenzoate obtained in Example (175a) (78 mg, 0.19 mmol) and a 10% palladium-carbon catalyst (100 mg), to obtain the title compound as a yellow oily substance. The resulting compound was used for the next reaction without purification.
Sources & evidence
- ORD record
- ord-779ec1d43e634130a37bf326bdc3e717
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08536197B2
Reaction notes
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