HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-3-hydroxybutanoic acid → N-(2,3,4,5,6-pentahydroxy-hexyl)-DL-threonine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-3-hydroxybutanoic acid | HCID 205 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal | HCID 107526 | — |
| Catalyst | Nickel | HCID 935 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-(2,3,4,5,6-pentahydroxy-hexyl)-DL-threonine | HCID 21427714 | — |
Reaction Steps
The starting materials were D-glucose and DL-threonine. The reductive amination was carried out using Raney nickel or palladium/activated carbon (10%) and yielded a product having a melting point of 219° C. (decomposition) and a RF -value of 0.67 (determined on DC-finished plates of silica gel G (Merck) with a transporting fluid made up of 75 parts by volume of methanol and 25 parts by volume of water).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04032676 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-0045e3d370ba48e49958eaef34400e88 |
| Source note | uspto-grants-1977_06 |