Acetic Anhydride → HCID 18188084, compound

HRID 439313

Reaction equation

HRID 439313 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=[O:6].[C:14](OC(=O)C)(=[O:16])[CH3:15]>N1C=CC=CC=1>[C:14]([O:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=[O:6])(=[O:16])[CH3:15]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 692653-Hydroxy-4-nitrobenzoic acid

Product 1

HCID 18188084HCID 18188084, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The 3-hydroxy-4-nitrobenzoic acid starting material is acetylated using, for instance, acetic anhydride and pyridine at reflux temperatures for 1-4 hours to afford 3-acetoxy-4-nitrobenzoic acid. This compound is then dissolved in a non-polar, aprotic solvent, such as benzene or toluene, and refluxed with thionyl chloride for a period of about 2-6 hours to form the desired 3-acetoxy-4-nitrobenzoyl chloride.

Workup

  1. temperatureat reflux temperatures for 1-4 hours

Sources & evidence

ORD record
ord-ce8d26d8c9054ebb85776972499d1316
Source dataset
uspto-grants-1996_05
Patent number
US05514676

Linked notes

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