HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Benzyl 4-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Product | Benzyl 4-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate | HCID 21981786 | 81.1% |
Reaction Steps
The same operation as in Example (227a) was performed using 4-[(tert-butoxycarbonyl)amino]piperidine (2.00 g, 9.99 mmol), benzyl chloroformate (2.14 mL, 15.0 mmol) and triethylamine (3.48 mL, 25.0 mmol), to obtain 2.71 g of the title compound as a white solid (81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536197B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-62ef6d9df10048689be273132c9cefaf |
| Source note | uspto-grants-2013_09 |