Benzenesulfonyl chloride → HCID 15453203, compound

Reaction equation

[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][C:12]1[O:16][N:15]=[C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:13]=1[Br:23]>>[C:17]1([C:14]2[C:13]([Br:23])=[C:12]([NH:11][S:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)(=[O:9])=[O:8])[O:16][N:15]=2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

Reactant 2

HCID 7369Benzenesulfonyl chloride

HCID 5829115-Amino-4-bromo-3-phenylisoxazole

Product 1

HCID 15453203HCID 15453203, compoundYield 36%

Procedure

This compound was prepared from benzenesulfonyl chloride and 5-amino-4-bromo-3-phenylisoxazole according to the method in Example 1b in 36% yield. Recrystallization from methanol gave a yellow solid, m.p. 113°-115° C.

Workup

customRecrystallization from methanol
customgave a yellow solid, m.p. 113°-115° C.

Sources & evidence

ORD record: ord-88fc2f926e024b65a9b61af52b660736
Source dataset: uspto-grants-1996_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05514691

Reaction notes

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