Methanol → Benzoic acid, 4-ethyl-, methyl ester

HRID 439794

Reaction equation

HRID 439794 reaction equation
[CH2:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1)[CH3:2].S(Cl)(Cl)=O.[CH3:16]O>>[CH2:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([O:9][CH3:16])=[O:8])=[CH:5][CH:4]=1)[CH3:2]

Participants

4

Reactant 3

HCID 887MethanolHCID 120864-Ethylbenzoic AcidHCID 24386Thionyl Chloride

Product 1

HCID 23827Benzoic acid, 4-ethyl-, methyl ester

Procedure

A mixture of 4-ethylbenzoic acid (5.12 g), thionyl chloride (3.0 ml) and methanol (150 ml) was heated and refluxed. After 3 hours, the mixture was concentrated under reduced pressure to give methyl 4-ethylbenzoate (5.59 g). this product was used in the subsequent step without purification.

Workup

  1. temperaturewas heated
  2. temperaturerefluxed
  3. concentrationthe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-cfb03ca1633a47faa484d1cc6cde5262
Source dataset
uspto-grants-1996_05
Patent number
US05516777

Linked notes

Loading…