1-(3-Nitropyridin-2-yl)piperazine → 2-(Piperazin-1-yl)pyridin-3-amine

HRID 440244

Reaction equation

HRID 440244 reaction equation
[N+:1]([C:4]1[C:5]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O.[H][H]>CO.[C].[Pd]>[NH2:1][C:4]1[C:5]([N:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)=[N:6][CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 37788341-(3-Nitropyridin-2-yl)piperazineHCID 178418361HCID 178418361, compound

Product 1

HCID 103973582-(Piperazin-1-yl)pyridin-3-amineYield 95.8%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

In 30 ml of methanol was dissolved 3.13 g (0.015 mole) of 1-(3-nitro-2-pyridyl)piperazine, and 2 g of 5% palladium carbon was added thereto. While stirring the mixture at room temperature, hydrogen gas was passed through for one hour. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to obtain 2.56 g of 1-(3-amino-2-pyridyl)piperazine as pale yellow liquid.

Workup

  1. additionwas added
  2. customwas passed through for one hour
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ddd5187149e74fe9b7a86c02188a48f5
Source dataset
uspto-grants-1996_05
Patent number
US05519016

Linked notes

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