Cinchomeronic acid → 1H,3H-furo(3,4-c)pyridine-1,3-dione

HRID 440350

Reaction equation

HRID 440350 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=O)=[C:3]([C:10]([OH:12])=[O:11])[CH:2]=1>C(OC(=O)C)(=O)C>[N:1]1[CH:6]=[CH:5][C:4]2[C:7]([O:12][C:10](=[O:11])[C:3]=2[CH:2]=1)=[O:9]

Participants

3

Reactant 1

HCID 10273Cinchomeronic acid

Product 1

HCID 2783981H,3H-furo(3,4-c)pyridine-1,3-dioneYield 75.5%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A mixture of pyridine 3,4-dicarboxylic acid (15.0 g) and acetic anhydride (30 mL) is refluxed for two hours. The excess acetic anhydride is removed by distillation and the anhydride is collected and purified by sublimation (123° C. at 3 mm Hg) to yield pyridine 3,4-dicarboxylic acid anhydride as a white solid (10.1 g).

Workup

  1. temperatureis refluxed for two hours
  2. customThe excess acetic anhydride is removed by distillation
  3. customthe anhydride is collected
  4. custompurified by sublimation (123° C. at 3 mm Hg)

Sources & evidence

ORD record
ord-008e67ff95cd4f68ad40055b4987af1f
Source dataset
uspto-grants-1996_05
Patent number
US05519029

Linked notes

Loading…