Thionyl Chloride → 6-(2-Thienyl)pyridine-3-carbonyl chloride

HRID 440767

Reaction equation

HRID 440767 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:11]=[CH:10][C:9]([C:12]([OH:14])=O)=[CH:8][CH:7]=1.S(Cl)([Cl:17])=O>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:11]=[CH:10][C:9]([C:12]([Cl:17])=[O:14])=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 154111446-(Thiophen-2-Yl)Pyridine-3-Carboxylic Acid

Product 1

HCID 178790336-(2-Thienyl)pyridine-3-carbonyl chloride

Procedure

A mixture of 1.8 g of 6-(2-thienyl)pyridine-3-carboxylic acid in 50 ml of thionyl chloride is refluxed under dry conditions for 1 hour. The reaction mixture is evaporated to dryness and evaporated again from 50 ml of carbon tetrachloride to a residue. The residue is dissolved in 60 ml of methylene chloride and used further reactions.

Workup

  1. temperatureis refluxed under dry conditions for 1 hour
  2. customThe reaction mixture is evaporated to dryness
  3. customevaporated again from 50 ml of carbon tetrachloride to a residue
  4. dissolutionThe residue is dissolved in 60 ml of methylene chloride

Sources & evidence

ORD record
ord-91e25bf160764e81b0ace79c715a5053
Source dataset
uspto-grants-1996_05
Patent number
US05521173

Linked notes

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