Mannitol → Docetaxel Mannitol

HRID 44128

Reaction equation

HRID 44128 reaction equation
[CH2:1]([OH:12])[C@H:2]([C@H:4]([C@@H:6]([C@@H:8]([CH2:10][OH:11])[OH:9])[OH:7])[OH:5])[OH:3].[CH3:13][C:14]1[C@@H:31]([O:32][C:33]([C@H:35]([OH:51])[C@@H:36]([NH:43][C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])[C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)=[O:34])[CH2:30][C@:26]2([OH:52])[C:27]([CH3:29])([CH3:28])[C:15]=1[C@@H:16]([OH:70])[C:17]([C@@:19]1([CH3:69])[C@H:24]([C@@H:25]2[O:53][C:54]([C:56]2[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=2)=[O:55])[C@:23]2([O:64][C:65]([CH3:67])=[O:66])[CH2:62][O:63][C@@H:22]2[CH2:21][C@@H:20]1[OH:68])=[O:18].C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.O>>[CH3:13][C:14]1[C@@H:31]([O:32][C:33]([C@H:35]([OH:51])[C@@H:36]([NH:43][C:44]([O:46][C:47]([CH3:48])([CH3:49])[CH3:50])=[O:45])[C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)=[O:34])[CH2:30][C@:26]2([OH:52])[C:27]([CH3:28])([CH3:29])[C:15]=1[C@@H:16]([OH:70])[C:17]([C@@:19]1([CH3:69])[C@H:24]([C@@H:25]2[O:53][C:54]([C:56]2[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=2)=[O:55])[C@:23]2([O:64][C:65]([CH3:67])=[O:66])[CH2:62][O:63][C@@H:22]2[CH2:21][C@@H:20]1[OH:68])=[O:18].[CH2:10]([OH:11])[C@H:8]([C@H:6]([C@@H:4]([C@@H:2]([CH2:1][OH:12])[OH:3])[OH:5])[OH:7])[OH:9]

Participants

4

Reactant 3

HCID 6251MannitolHCID 148124DocetaxelHCID 22814120Glucose Monohydrate

Product 1

HCID 86641782Docetaxel Mannitol

Procedure

An aliquot of the mannitol solution was added to the vessel containing the docetaxel solution, which was then re-sealed and mixed until homogeneous (about 15 minutes) at about 600-800 RPM. The mixed solution was then filtered, and a number of pre-sterilized lyophilization vials were aseptically filled with the filtered solution. The vials were immediately transferred to a freeze-dryer and lyophilized under vacuum using nitrogen. A lyophilizate was obtained, and used to reconstitute clear solutions with the sucrose fatty acid ester diluent. The clear solution was further diluted for administrative purposes in saline and D5W. Stability measurements indicated that the solutions remained clear and non-precipitated after 24 hours.

Workup

  1. customwas then re-sealed
  2. additionmixed until homogeneous (about 15 minutes) at about 600-800 RPM
  3. filtrationThe mixed solution was then filtered
  4. additiona number of pre-sterilized lyophilization vials were aseptically filled with the filtered solution
  5. customA lyophilizate was obtained

Sources & evidence

ORD record
ord-0581785b1df846d9a5c06ef2f4827f09
Source dataset
uspto-grants-2013_09
Patent number
US08541360B2

Linked notes

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