Mannitol → Docetaxel Mannitol

HRID 44129

Reaction equation

[CH3:1][C:2]1[C@@H:19]([O:20][C:21]([C@H:23]([OH:39])[C@@H:24]([NH:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[O:22])[CH2:18][C@:14]2([OH:40])[C:15]([CH3:17])([CH3:16])[C:3]=1[C@@H:4]([OH:58])[C:5]([C@@:7]1([CH3:57])[C@H:12]([C@@H:13]2[O:41][C:42]([C:44]2[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=2)=[O:43])[C@:11]2([O:52][C:53]([CH3:55])=[O:54])[CH2:50][O:51][C@@H:10]2[CH2:9][C@@H:8]1[OH:56])=[O:6].[CH2:59]([OH:70])[C@H:60]([C@H:62]([C@@H:64]([C@@H:66]([CH2:68][OH:69])[OH:67])[OH:65])[OH:63])[OH:61]>>[CH3:1][C:2]1[C@@H:19]([O:20][C:21]([C@H:23]([OH:39])[C@@H:24]([NH:31][C:32]([O:34][C:35]([CH3:36])([CH3:37])[CH3:38])=[O:33])[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[O:22])[CH2:18][C@:14]2([OH:40])[C:15]([CH3:16])([CH3:17])[C:3]=1[C@@H:4]([OH:58])[C:5]([C@@:7]1([CH3:57])[C@H:12]([C@@H:13]2[O:41][C:42]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)=[O:43])[C@:11]2([O:52][C:53]([CH3:55])=[O:54])[CH2:50][O:51][C@@H:10]2[CH2:9][C@@H:8]1[OH:56])=[O:6].[CH2:68]([OH:69])[C@H:66]([C@H:64]([C@@H:62]([C@@H:60]([CH2:59][OH:70])[OH:61])[OH:63])[OH:65])[OH:67]

Participants

Reactant 2

HCID 6251Mannitol2×

HCID 148124Docetaxel2×

Product 1

HCID 86641782Docetaxel Mannitol

Procedure

Lyophilization is performed to yield vials containing lyophilized cake comprising docetaxel and mannitol in a ratio of 1:1.5 to 1:3, preferably 1:1.8 to 1:2.7, more preferably 1:2.0 to 1:2.5, and most preferably 1:2.2. The amount of cake may vary, for example a 1:2.2 ratio may be obtained by a vial comprising 20 mg docetaxel and 44 mg mannitol, a vial comprising 80 mg docetaxel and 176 mg mannitol, or a vial comprising 120 mg docetaxel and 264 mg mannitol.

Sources & evidence

ORD record: ord-27e97dd5f81c4864a82e99c54caa86b2
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08541360B2

Linked notes

Loading…