Butylamine → HCID 135623124, compound

Reaction equation

[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[CH2:9][S:10]([CH3:12])=[O:11].[CH2:14]([NH2:18])[CH2:15][CH2:16][CH3:17]>>[CH2:14]([N:18]=[C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[OH:1])[CH2:9][S:10]([CH3:12])=[O:11])[CH2:15][CH2:16][CH3:17]

Participants

Reactant 2

HCID 8007Butylamine

HCID 578088HCID 578088, compound

Product 1

HCID 135623124HCID 135623124, compoundYield 95%

Procedure

A solution of 2'-hydroxy-2-(methylsulfinyl)acetophenone (15 g, 0.076 mole) in n-butylamine (75 ml) was stirred at room temperature for 16 hrs. The reaction mixture was poured into petroleum ether (500 ml) and the product, which precipitated, was filtered off. Recrystallization from ethylacetate-cyclohexane gave yellow crystals (18.2 g, 95%), mp 128°-129°.

Workup

customthe product, which precipitated
filtrationwas filtered off
customRecrystallization from ethylacetate-cyclohexane

Sources & evidence

ORD record: ord-84792e350263417ba3a2869b3efb6861
Source dataset: uspto-grants-1977_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04039579

Reaction notes

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