Chloromethyl methyl sulfide → 2-Methyl-3-(((methylthio)methyl)thio)furan

HRID 441619Notes

Reaction equation

HRID 441619 reaction equation
C[O-].[Na+].[CH3:4][C:5]1[O:6][CH:7]=[CH:8][C:9]=1[SH:10].[CH3:11][S:12][CH2:13]Cl>CO>[CH3:4][C:5]1[O:6][CH:7]=[CH:8][C:9]=1[S:10][CH2:11][S:12][CH3:13]

Participants

5

Reactant 3

HCID 16916Chloromethyl methyl sulfideHCID 342862-Methyl-3-furanthiolHCID 10942334Sodium Methoxide

Product 1

HCID 215030942-Methyl-3-(((methylthio)methyl)thio)furan

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Into a 25 ml round bottom flask equipped with magnetic stirrer, thermometer, water bath, and reflux condenser is added a solution containing 0.27 g of sodium methoxide (0.005 moles) in 3 ml. absolute methanol. While maintaining the solution at 25° - 30° C., 0.57 g (0.005 moles) of 2-methyl-3-furan thiol in 2 ml of absolute methanol is added thereto. At 25° C., 0.483 g (0.005 moles) of chloromethyl methyl sulfide having the formula:

Workup

  1. customInto a 25 ml round bottom flask equipped with magnetic stirrer
  2. temperaturethermometer, water bath, and reflux condenser
  3. additionis added a solution
  4. temperatureWhile maintaining the solution at 25° - 30° C.
  5. customAt 25° C.

Sources & evidence

ORD record
ord-67b28da5b74043d7b645f9bb99bd1a0d
Source dataset
uspto-grants-1977_08
Patent number
US04041186

Reaction notes

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