Sodium Methoxide → 2,7-Bis(4-piperidinobutoxy)fluorene dihydrochloride

Reaction equation

[N:1]1([CH2:7][CH2:8][CH2:9][CH2:10][Cl:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O[C:13]1[CH:25]=[CH:24][C:23]2[C:22]3[C:17](=[CH:18][C:19]([OH:26])=[CH:20][CH:21]=3)[CH2:16][C:15]=2[CH:14]=1.[CH3:27][O-:28].[Na+]>C1(C)C=CC=CC=1>[ClH:11].[ClH:11].[N:1]1([CH2:7][CH2:8][CH2:9][CH2:27][O:28][C:13]2[CH:25]=[CH:24][C:23]3[C:22]4[C:17](=[CH:18][C:19]([O:26][CH2:10][CH2:9][CH2:8][CH2:7][N:1]5[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]5)=[CH:20][CH:21]=4)[CH2:16][C:15]=3[CH:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Procedure

A solution of 13.1 g (0.075 mole) of 4-piperidinobutyl chloride in 100 ml of toluene is added to a mixture of 4.9 g (0.025 mole) of 2,7-dihydroxyfluorene and 2.7 g (0.05 mole) of sodium methoxide in 200 ml of toluene. The mixture is refluxed with stirring for 12 hours. Upon cooling, the mixture is filtered to remove the precipitated sodium chloride. The toluene solution is washed with water, then with sodium chloride solution and dried over anhydrous magnesium sulfate. This mixture is filtered and the filtrate acidified to Congo Red with ethereal HCl. The precipitate is collected and recrystallized from butanone-methanol to give 2,7-bis(4-piperidinobutoxy)fluorene dihydrochloride.