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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 441753Generated: October 27, 2026

Phenolate Sodium → 2-Amino-3-morpholino-5-phenoxypyrazine

https://huagongshe.com/reaction/441753

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenolate SodiumHCID 4445035—
Reactant2-Amino-3-morpholino-4-bromopyrazineHCID 53693233—
Product2-Amino-3-morpholino-5-phenoxypyrazineHCID 20528948—

Reaction Steps

A suspension of 0.1 mole of sodium phenoxide and 0.1 mole of 2-amino-3-morpholino-4-bromopyrazine is refluxed 10- 20 hours. The cooled mixture is extracted with diethyl ether, washed with cold 2N sodium hydroxide solution, dried and evaporated to give 2-amino-3-morpholino-5-phenoxypyrazine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04042586
Source datasetuspto-grants-1977_08
ORD IDord-eb7cf89b95704585b431a99c17c81cc5
Source noteuspto-grants-1977_08