Dimethylamine → HCID 21416502, compound
Reaction equation
[CH3:1][NH:2][CH3:3].Cl[CH2:5][C:6]([CH:8]1[CH2:13][CH:12]2[CH2:14][CH:9]1[CH:10]=[CH:11]2)=[O:7]>CCOCC>[CH3:1][N:2]([CH2:5][C:6]([CH:8]1[CH2:13][CH:12]2[CH2:14][CH:9]1[CH:10]=[CH:11]2)=[O:7])[CH3:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 3.5 g (5.2 ml; 0.078 mole) of dimethylamine in 40 ml of ether at -15° was added 6.5 g (0.038 mole) of 5-chloroacetyl-2-norbornene. The reaction mixture was stirred for 7 hr. at 0° (ice bath) and then allowed to warm to room temperature overnight. The solid dimethylamine hydrochloride was removed by filtration and the ether was removed at reduced pressure to give 6.1 g (89%) of crude product. Distillation gave product bp 83°-90°/0.8 mm.
Workup
- customat 0°
- customThe solid dimethylamine hydrochloride was removed by filtration
- customthe ether was removed at reduced pressure
- customto give 6.1 g (89%) of crude product
- distillationDistillation
Sources & evidence
- ORD record
- ord-bbe4504d8f3447c79e1d0ae3dc2e2739
- Source dataset
- uspto-grants-1977_08
- Patent number
- US04044054
Reaction notes
Loading…