Thionyl Chloride → p-Chloromethylphenylacetyl chloride

HRID 442346

Reaction equation

[Cl:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1.S(Cl)([Cl:15])=O>>[Cl:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([Cl:15])=[O:12])=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 24386Thionyl Chloride2×

HCID 103134194-(Chloromethyl)phenylacetic acid

Product 1

HCID 20380233p-Chloromethylphenylacetyl chloride

Procedure

A mixture of 1 g of p-chloromethylphenylacetic acid and 6 ml of thionyl chloride is stirred at room temperature for 25 hours after which the excess thionyl chloride is removed under vacuum to yield p-chloromethylphenylacetyl chloride.

Workup

customis removed under vacuum

Sources & evidence

ORD record: ord-05a6d14492d4416e891aa8b6f6a8d12a
Source dataset: uspto-grants-1977_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04045438

Linked notes

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