Diisopropylamine → Diisopropylammonium 2-propyl-5-thiazolecarboxylate

HRID 442494

Reaction equation

HRID 442494 reaction equation
[CH2:1]([C:4]1[S:5][C:6]([C:9]([OH:11])=[O:10])=[CH:7][N:8]=1)[CH2:2][CH3:3].[CH:12]([NH:15][CH:16]([CH3:18])[CH3:17])([CH3:14])[CH3:13]>CC(C)=O>[CH2:1]([C:4]1[S:5][C:6]([C:9]([O-:11])=[O:10])=[CH:7][N:8]=1)[CH2:2][CH3:3].[CH:12]([NH2+:15][CH:16]([CH3:18])[CH3:17])([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 7912DiisopropylamineHCID 65773Tizoprolic Acid

Product 1

HCID 21415066Diisopropylammonium 2-propyl-5-thiazolecarboxylateYield 90%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4.45 Grams of 2-propyl-5-thiazolecarboxylic acid (obtained in Example II) are dissolved in 120 cc of acetone and 2.62 gm of diisopropylamine are added. The solvent is evaporated off under low pressure and the crystals thus obtained are recrystallized from isopropyl ether. The diisopropylammonium 2-propyl-5-thiazolecarboxylate is obtained in the form of colorless crystals, soluble in water and in alcohol, melting at 120° C. (Yield: 90%).

Workup

  1. customThe solvent is evaporated off under low pressure
  2. customthe crystals thus obtained
  3. customare recrystallized from isopropyl ether

Sources & evidence

ORD record
ord-378c935309a3447ca2cda4daca4c765c
Source dataset
uspto-grants-1977_08
Patent number
US04045567

Linked notes

Loading…