p-Chlorophenacyl bromide → 1-(4-Chlorophenyl)-2-hydroxyethan-1-one

HRID 44286

Reaction equation

HRID 44286 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4].C([O-])=[O:13].[K+]>CO>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][OH:13])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 68303p-Chlorophenacyl bromideHCID 2735122Potassium Formate

Product 1

HCID 5870851-(4-Chlorophenyl)-2-hydroxyethan-1-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-bromo-1-(4-chloro-phenyl)-ethanone (100 mmoles) and potassium formate (130 mmoles) in MeOH (100 ml) is stirred at reflux for 3 hours. The reaction mixture is poured onto crushed ice. The solid formed is filtered off, washed with cold MeOH and then dried in vacuo to yield the title product, which is used directly in the next Step.

Workup

  1. temperatureat reflux for 3 hours
  2. additionThe reaction mixture is poured
  3. customonto crushed ice
  4. customThe solid formed
  5. filtrationis filtered off
  6. washwashed with cold MeOH
  7. customdried in vacuo

Sources & evidence

ORD record
ord-ab2f5eac5e324d2490f3ca2c3523ed47
Source dataset
uspto-grants-2013_09
Patent number
US08541412B2

Linked notes

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