Propionylhydrazine → 3-Ethyl-6-(2-pyridyl)-1,2,4-triazolo[4,3-b]pyridazine

HRID 443518

Reaction equation

HRID 443518 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:6][CH:7]=1.[C:14]([NH:18][NH2:19])(=O)[CH2:15][CH3:16]>C(O)CCC>[CH2:15]([C:14]1[N:3]2[N:4]=[C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=3)[CH:6]=[CH:7][C:2]2=[N:19][N:18]=1)[CH3:16]

Participants

4

Reactant 2

HCID 79890PropionylhydrazineHCID 64179603-Chloro-6-(pyridin-2-yl)pyridazine

Product 1

HCID 234675733-Ethyl-6-(2-pyridyl)-1,2,4-triazolo[4,3-b]pyridazine

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

As for Example 4, a mixture of 1.0 g. of 3-chloro-6-(2-pyridyl)pyridazine, propionic acid hydrazide and 50 ml. of n-butyl alcohol is refluxed for 48 hours to give the product of the Example.

Workup

  1. additionAs for Example 4, a mixture of 1.0 g
  2. customto give the product of the Example

Sources & evidence

ORD record
ord-100b3799e3ca489c83e5eed97dedb397
Source dataset
uspto-grants-1981_04
Patent number
US04260756

Linked notes

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