O-Methylhydroxylamine → 2-(Methoxyamino)quinazolin-4-amine

HRID 44374

Reaction equation

HRID 44374 reaction equation
Cl[C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[O:13]([NH2:15])[CH3:14]>>[CH3:14][O:13][NH:15][C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 4113O-MethylhydroxylamineHCID 2528792-Chloroquinazolin-4-amine

Product 1

HCID 574569212-(Methoxyamino)quinazolin-4-amine

Procedure

Prepared as in Example 42 from 2-chloroquinazolin-4-amine (Example 38) and methoxylamine. 1H NMR (400 MHz, DMSO-d6) δ3.79 (s, 3H), 7.48-7.44 (m, 1H), 7.86-7.80 (m, 2H), 8.27 (d, J=8.0 Hz, 1H), 8.99 (s, 1H), 9.16 (s, 1H), 12.39-12.08 (m, 1H). MS 191 (MH+).

Sources & evidence

ORD record
ord-0159be6d9c5b4e1189b29725576be9e0
Source dataset
uspto-grants-2013_09
Patent number
US08541421B2

Linked notes

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