Bromine → 2,4-Dibromo-6-bromomethylanisole
Reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[O:10][CH3:11].[Br:12]Br>ClC(Cl)(Cl)Cl.C(OOCC1C=CC=CC=1)C1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([CH2:9][Br:12])[C:3]=1[O:10][CH3:11]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of the product of stage (b) (200 g) and benzyl peroxide (1 g) in tetrachloromethane (600 ml) was heated to reflux with stirring. Bromine (114 g) was added dropwise, and the mixture was stirred until it cooled to room temperature. Evaporation of the solvent gave an oil, distillation of which gave the title compound (183 g) as an oil, bp 115°-116° C./0.3 mm Hg.
Workup
- temperatureto reflux
- stirringthe mixture was stirred until it
- customEvaporation of the solvent
- customgave
- distillationan oil, distillation of which
Sources & evidence
- ORD record
- ord-9859723e10a2467ca6b64c6b4d7726df
- Source dataset
- uspto-grants-1981_04
- Patent number
- US04263037
Reaction notes
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