[CH:1]1[C:6]2[CH2:7][NH:8][C:9]3[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=3[S:11](=[O:13])(=[O:12])[C:5]=2[CH:4]=[C:3]([C:18]([O:20]C)=[O:19])[CH:2]=1.[OH-].[K+].O.C(O)C>O1CCOCC1>[CH:1]1[C:6]2[CH2:7][NH:8][C:9]3[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=3[S:11](=[O:13])(=[O:12])[C:5]=2[CH:4]=[C:3]([C:18]([OH:20])=[O:19])[CH:2]=1Stir a mixture of 3.03 gm. (10 mmole) of the ester of Example 15, 2.24 gm. (20 mmole) of 85% aqueous potassium hydroxide, 11 ml. of water, 55 ml. of ethanol and 5.5 ml. of dioxane under nitrogen for 2 hours. Concentrate the reaction mixture to the point of crystallization and dilute with 40 ml. of water. Filter and acidify with acetic acid. Separate the precipitate by filtration and wash with water and dry to obtain the title product (m.p. 304°-306° C.).
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