10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepin-3-carboxylic acid → HCID 23464472, compound
Reaction equation
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[S:6][C:5]2[CH:13]=[C:14]([C:17]([OH:19])=O)[CH:15]=[CH:16][C:4]=2[NH:3]1.O=C1C2C=CC(C(O)=O)=CC=2SC2C=CC=CC=2[NH:22]1>>[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[S:6][C:5]2[CH:13]=[C:14]([C:17]([NH2:22])=[O:19])[CH:15]=[CH:16][C:4]=2[NH:3]1Participants
3
Procedure
In a similar manner, substituting 10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepin-7-carboxylic acid for the 10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepin-3-carboxylic acid in Step A, there is obtained 10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepin-7-carboxamide. Carboxamides of 10,11-dihydrodibenzo[b,f][1,4]thiazepin-3(or 7)-carboxylic acid or dibenzo[b,f][1,4]thiazepin-3(or 7)-carboxylic acid are prepared by the process of Example 33, by substituting the desired 3(or 7) carboxylic acid for the starting material of Step A.
Sources & evidence
- ORD record
- ord-0c7bbb31e2df401e9872cb0b8df88883
- Source dataset