Dimethylamine → SBB061064

HRID 444188

Reaction equation

HRID 444188 reaction equation
Cl[CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10].[CH3:11][NH:12][CH3:13]>>[CH3:11][N:12]([CH3:13])[CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 788712-(2-(2-Chloroethoxy)ethoxy)ethanol

Product 1

HCID 10845034SBB061064

Procedure

Commercial Cl(CH2CH2O)3H (abb. ClE3H) (2.0 mole) and dimethylamine (20.0 mole) were mixed in a flask (3.0 l) fitted with a condenser and stirred (RT) for 30 hours. TLC (Si-gel) examination showed the complete consumption of the ClE3H. Excess dimethylamine was removed by two consecutive evaporations under reduced pressure. The residual material was reconstituted in CHCl3, dried (MgSO4), filtered and evaporated to dryness to produce the product, 8-dimethylamino-3,6-dioxaoctanol.

Workup

  1. customfitted with a condenser
  2. customthe complete consumption of the ClE3H
  3. customExcess dimethylamine was removed by two consecutive evaporations under reduced pressure
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-640529c8258d4e74a8dd8c70eedc4121
Source dataset
uspto-grants-1981_04
Patent number
US04263281

Linked notes

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