Methanol → HCID 58170002, compound
Reaction equation
O[O:2][S:3]([O-:5])=O.[K+].[NH2:7][C:8]1[N:9]=[C:10](SC)[S:11][C:12]=1[C:13](=[O:15])[CH3:14].[CH3:18]O>O>[NH2:7][C:8]1[N:9]=[C:10]([S:3]([CH3:18])(=[O:5])=[O:2])[S:11][C:12]=1[C:13](=[O:15])[CH3:14]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
2.775 g (4.52 mmol) of Oxone® were dissolved in 9 ml of water, and 500 mg (2.66 mmol) of 1-[4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl]ethanone, dissolved in 9 ml of methanol, were added dropwise at 5° C. The mixture was stirred at RT for 3 h, the methanol was reduced on a rotary evaporator and the residue was extracted twice with dichloromethane. Removal of the solvent gave 395 mg (52% of theory) of the product as a solid.
Workup
- additionwere added dropwise at 5° C
- customthe methanol was reduced on a rotary evaporator
- extractionthe residue was extracted twice with dichloromethane
- customRemoval of the solvent
Sources & evidence
- ORD record
- ord-97531cf247564fdd8cb983ed19390134
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08476267B2
Reaction notes
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