N-(1H-indazol-5-yl)-2-azabicyclo[2.2.2]octan-4-amine → 2-(5-((4-((1H-indazol-5-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methyl)-2-methylphenoxy)ethanol

HRID 445134

Reaction equation

HRID 445134 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([NH:10][C:11]34[CH2:18][CH2:17][CH:14]([CH2:15][CH2:16]3)[NH:13][CH2:12]4)=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[OH:19][CH2:20][CH2:21][O:22][C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][C:30]=1[CH3:31])[CH:26]=O>>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([NH:10][C:11]34[CH2:16][CH2:15][CH:14]([CH2:17][CH2:18]3)[N:13]([CH2:26][C:25]3[CH:28]=[CH:29][C:30]([CH3:31])=[C:23]([CH:24]=3)[O:22][CH2:21][CH2:20][OH:19])[CH2:12]4)=[CH:7][CH:8]=2)[CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 67234936N-(1H-indazol-5-yl)-2-azabicyclo[2.2.2]octan-4-amineHCID 86654428HCID 86654428, compound

Product 1

HCID 532458572-(5-((4-((1H-indazol-5-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methyl)-2-methylphenoxy)ethanol

Procedure

Reaction of Intermediate 26 with 3-(2-hydroxyethoxy)-4-methylbenzaldehyde affords the title compound.

Sources & evidence

ORD record
ord-1632baee3e5847389eb916d6042a3834
Source dataset
uspto-grants-2013_07
Patent number
US08476295B2

Linked notes

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