HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 445185Generated: October 26, 2026
Potassium Carbonate → 1-(2-hydroxy-2-phenyl-ethyl)-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one
https://huagongshe.com/reaction/445185
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Epoxy-styrene | HCID 14299145 | — |
| Reactant | 4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one | HCID 59259137 | — |
| Catalyst | Benzyl triethylammonium chloride | HCID 66133 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(2-hydroxy-2-phenyl-ethyl)-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one | HCID 60112778 | — |
Reaction Steps
A mixture of 2.00 g (6.28 mmol) 4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one, 0.72 ml (6.28 mmol) epoxy-styrene, 0.143 g (0.628 mmol) benzyl-triethylammonium chloride (TEBA), 0.086 g (0.628 mmol) potassium carbonate and 5 ml dioxane is heated at 90° C. for 18 h. Aqueous work up followed by chromatography on silica gives 1-(2-hydroxy-2-phenyl-ethyl)-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08476286B2 |
|---|
| Source dataset | uspto-grants-2013_07 |
|---|
| ORD ID | ord-93e8e8faa5fb407c81a1a0371cbcaf11 |
|---|
| Source note | uspto-grants-2013_07 |
|---|
