3-Propylphenol → 2-Chloro-4-(3-propylphenoxy)benzaldehyde

Reaction equation

[CH2:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)[CH2:2][CH3:3].[Cl:11][C:12]1[CH:19]=[C:18](F)[CH:17]=[CH:16][C:13]=1[CH:14]=[O:15]>>[Cl:11][C:12]1[CH:19]=[C:18]([O:10][C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([CH2:1][CH2:2][CH3:3])[CH:5]=2)[CH:17]=[CH:16][C:13]=1[CH:14]=[O:15]

Participants

Reactant 2

HCID 693023-Propylphenol

HCID 1450242-Chloro-4-fluorobenzaldehyde

Product 1

HCID 580225952-Chloro-4-(3-propylphenoxy)benzaldehyde

Procedure

3-Propylphenol and 2-chloro-4-fluorobenzaldehyde were reacted according to the same experiment procedures as in Reference Example 1 of the pamphlet of WO 03029184 to obtain the target product as a pale brown oil.

Sources & evidence

ORD record: ord-b901e941cfa744f383e3e6fa89f00632
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08476305B2

Reaction notes

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