1,3-Difluoro-2-propanol → HCID 59619636, compound

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([OH:9])[C:5]([CH3:8])=[N:6][CH:7]=1.[F:10][CH2:11][CH:12](O)[CH2:13][F:14]>>[Br:1][C:2]1[CH:3]=[C:4]([O:9][CH:12]([CH2:13][F:14])[CH2:11][F:10])[C:5]([CH3:8])=[N:6][CH:7]=1

Participants

Reactant 2

HCID 679851,3-Difluoro-2-propanol

HCID 132279685-Bromo-2-methylpyridin-3-ol

Product 1

HCID 59619636HCID 59619636, compound

Procedure

The title compound was synthesized in a similar manner as described for stage 58.1.2 using 5-bromo-2-methyl-pyridin-3-ol (stage 189.1.2, 2.234 mmol) and 1,3-difluoro-2-propanol (Aldrich, Buchs, Switzerland, 2.68 mmol) to give the title compound as a yellow oil. (HPLC: tR 2.41 min (Method A); M+H=266, 268 MS-ES).

Workup

customThe title compound was synthesized in a similar manner

Sources & evidence

ORD record: ord-481f5e935437463ea83fa4f4e1b702a6
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08476294B2

Reaction notes

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