2-Methyl-2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)propanenitrile → 2-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-yl}-2-methyl-propionitrile

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A) and 2-methyl-2-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-3-yl]-propionitrile (Stage 220.1.1) to give the title compound as a white solid. (HPLC: tR 2.36 min (Method A); M+H=438 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 9.01 (s, 1H), 8.78-8.76 (m, 1H), 8.73-8.71 (m, 1H), 8.18-8.14 (m, 1H), 8.12 (s, 1H), 8.05-8.01 (m, 1H), 7.93-7.90 (m, 1H), 7.62-7.60 (m, 1H), 3.88 (s, 3H), 3.59 (s, 3H), 1.97 (s, 3H), 1.80 (s, 3H), 1.79 (s, 3H))

Provenance & Evidence