Thionyl Chloride → 3-Nitro-5-(trifluoromethyl)benzoyl chloride
Reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:12]=1)[C:7](O)=[O:8])([O-:3])=[O:2].S(Cl)([Cl:19])=O>>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:12]=1)[C:7]([Cl:19])=[O:8])([O-:3])=[O:2]Participants
3
Procedure
A solution of thionyl chloride (30 ml) and 3-nitro-5-(trifluoromethyl)benzoic acid (10 g) was heated to reflux for 2 h. The reaction mixture was concentrated under reduced pressure and treated with toluene (10 ml) which was then removed under reduced pressure to afford 3-nitro-5-(trifluoromethyl)benzoyl chloride.
Workup
- temperatureto reflux for 2 h
- concentrationThe reaction mixture was concentrated under reduced pressure
- additiontreated with toluene (10 ml) which
- customwas then removed under reduced pressure
Sources & evidence
- ORD record
- ord-d15a3f09a9ea4dde9675ae84279fc827
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08476434B2
Reaction notes
Loading…