5-Formyl-2-thiophenecarboxylic Acid → tert-Butyl (3-{[(5-formyl-2-thienyl)carbonyl](methyl)amino}propyl)methylcarbamate

HRID 446546

Reaction equation

HRID 446546 reaction equation
[CH:1]([C:3]1[S:7][C:6]([C:8]([OH:10])=O)=[CH:5][CH:4]=1)=[O:2].[CH3:11][N:12]([CH2:20][CH2:21][CH2:22][NH:23][CH3:24])[C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16]>>[CH:1]([C:3]1[S:7][C:6]([C:8]([N:23]([CH3:24])[CH2:22][CH2:21][CH2:20][N:12]([CH3:11])[C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:16])[CH3:17])=[O:10])=[CH:5][CH:4]=1)=[O:2]

Participants

3

Reactant 2

HCID 8188825-Formyl-2-thiophenecarboxylic AcidHCID 17868293tert-butyl N-methyl-N-(3-(methylamino)propyl)carbamate

Product 1

HCID 86663450tert-Butyl (3-{[(5-formyl-2-thienyl)carbonyl](methyl)amino}propyl)methylcarbamateYield 83%

Procedure

5-Formylthiophene-2-carboxylic acid (300 mg, 1.92 mmol) and tert-butyl methyl[3-(methylamino)propyl]carbamate (466 mg, 2.31 mmol) were used to give the title compound (517 mg; yield, 83%) as a colorless oily substance according to the method described in Example 41a.

Sources & evidence

ORD record
ord-fa8db9b52ca240499b6400f1f58a068e
Source dataset
uspto-grants-2013_07
Patent number
US08476253B2

Linked notes

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