Hydrazine → (R)-8-cyclopentyl-7-ethyl-2-hydrazinyl-5-methyl-7,8-dihydropteridin-6(5H)-one
Reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7](=[O:13])[C@@H:6]([CH2:14][CH3:15])[N:5]([CH:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[C:4]=2[N:3]=1.[NH2:21][NH2:22]>C(O)C>[CH:16]1([N:5]2[C:4]3[N:3]=[C:2]([NH:21][NH2:22])[N:11]=[CH:10][C:9]=3[N:8]([CH3:12])[C:7](=[O:13])[C@H:6]2[CH2:14][CH3:15])[CH2:20][CH2:19][CH2:18][CH2:17]1Participants
4
Procedure
Intermediate B and hydrazine (6 equivalents) in ethanol was heated in a microwave for 1 h at 120° C. The solvent was removed to give Intermediate B-2. This material was used without further purification.
Workup
- customThe solvent was removed
- customto give Intermediate B-2
- customThis material was used without further purification
Sources & evidence
- ORD record
- ord-c585cc71d7264df784cfa8261c1f44c5
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08541418B2
Reaction notes
Loading…