Sodium Hydroxide → HCID 68649743, compound
Reaction equation
C([O:3][C:4](=[O:18])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH:14]([F:17])[CH2:13][CH2:12]2)=[CH:7][CH:6]=1)C.[OH-].[Na+]>C(O)C>[F:17][CH:14]1[CH2:13][CH2:12][N:11]([C:8]2[CH:9]=[CH:10][C:5]([C:4]([OH:18])=[O:3])=[CH:6][CH:7]=2)[CH2:16][CH2:15]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 4-(4-fluoro-piperidin-1-yl)benzoic acid ethyl ester (0.7 g, 2.7 mmoles) in ethanol (50 ml) and a solution of 2N sodium hydroxide (20 ml) was stirred at room temperature for 24 hours. The ethanol was then evaporated, the solution diluted with water (20 ml) and neutralized with 2N HCl. The acid separated as a white solid which was washed with water and dried under vacuum (0.52 g, 82%).
Workup
- customThe ethanol was then evaporated
- additionthe solution diluted with water (20 ml)
- customThe acid separated as a white solid which
- washwas washed with water
- customdried under vacuum (0.52 g, 82%)
Sources & evidence
- ORD record
- ord-2dcb5eed15b84dbf92f877ebe6bea22f
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08481585B2
Reaction notes
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