Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl quinoline-6-carboxylate | HCID 736812 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Quinoline-6-carboxamide | HCID 11052097 | 88% |
Reaction Steps
To a solution of methyl quinoline-6-carboxylate (148 g, 0.79 mol) in methanol (600 ml.), aqueous ammonia (800 ml) was added and then stirred at 45° C. for 12 h. The reaction mixture was concentrated to afford the title compound as a dark red solid (120 g, 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08481739B2 |
|---|
| Source dataset | uspto-grants-2013_07 |
|---|
| ORD ID | ord-2064bc2c1664413890efaae10aeac9f7 |
|---|
| Source note | uspto-grants-2013_07 |
|---|
