Adipic Acid → 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;hexanedioate

HRID 449791Notes

Reaction equation

HRID 449791 reaction equation
[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([Cl:8])=[C:3]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][C:10]=2[NH2:16])[CH:2]=1.[C:17]([OH:26])(=[O:25])[CH2:18][CH2:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23]>CO>[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([Cl:8])=[C:3]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][C:10]=2[NH2:16])[CH:2]=1.[C:17]([O-:26])(=[O:25])[CH2:18][CH2:19][CH2:20][CH2:21][C:22]([O-:24])=[O:23]

Participants

4

Reactant 2

HCID 196Adipic AcidHCID 3878Lamotrigine

Product 1

HCID 866323226-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;hexanedioate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

16 mg of lamotrigine was dissolved in 2 ml of methanol, 11 mg of adipic acid was added to the solution to form a single solution. The solution was then allowed to stand for several hours to effect the slow evaporation of solvent. The solids gathered were stored in screw cap vials for subsequent analysis.

Workup

  1. customto form a single solution
  2. waitto stand for several hours
  3. customthe slow evaporation of solvent
  4. customcap vials for subsequent analysis

Sources & evidence

ORD record
ord-9374823017d143f1a784e1a60c0199c4
Source dataset
uspto-grants-2013_07
Patent number
US08486927B2

Reaction notes

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